Malformation Syndromes exert significant impact on individual patients and their families, with particularly negative effects on quality of life. However, studies focusing on the cognitive and behavioral characteristics of children with malformation syndromes are still limited, though this information is indispensable for the educational support of such children. The authors have already conducted a literature review focusing on malformation syndromes with the aim of contributing to the solution of this problem, however, many of the recent developments in research of this area are noteworthy. In this paper, we reviewed latest articles dealing with cognitive and behavioral characteristics of children with Malformation syndromes including Turner syndrome, Klinefelter syndrome, XYY syndrome, Triple X syndrome, Prader-Willi syndrome, Rubinstein-Taybi syndrome, Kabuki syndrome, Williams syndrome, congenital rubella syndrome, fetal alcohol syndrome and Spina Bifida myelomeningocele. Educational support for these children is also discussed.