New Aspects of Cadmium as Endocrine Disruptor

URI http://harp.lib.hiroshima-u.ac.jp/hirokoku-u/metadata/4645
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Title
New Aspects of Cadmium as Endocrine Disruptor
Author
氏名 瀧口 益史
ヨミ タキグチ マスフミ
別名 Takiguchi Masufumi
氏名 吉原 慎一
ヨミ ヨシハラ シンイチ
別名 Yoshihara Shinichi
Subject
endocrine disruptor
Cd
reproductive toxicity
Abstract

Cadmium (Cd) is an industrial and environmental pollutant that exerts adverse effects on a number of organs in humans and animals. Reproductive organs, such as the testis and placenta, are sensitive to the toxic effects of Cd. In animal experiments, high-dose exposure to Cd induced severe testicular interstitial hemorrhage with edema, and increased incidence of fetal death and placental necrosis. Low-dose exposure to Cd affects steroid synthesis in male and female reproductive organs. In 1998, the Ministry of Environment in Japan listed Cd in the strategy plan SPEED98 as one of the chemicals suspected of having possible endocrine disrupting activity. Recently, it has been shown that Cd has potent estrogen-and androgen-like activities in vivo and in vitro, by directly binding to estrogen and androgen receptors. However, the precise mechanisms underlying the effects of Cd as an endocrine disruptor remain to be elucidated. In this review, we will discuss evidence thus far presented concerning the effects of Cd on the endocrine system.

Journal Title
Environmental sciences : officially affiliated with the Japan Society of Endocrine Disrupters Research
Volume
13
Issue
2
Spage
107
Epage
116
Published Date
2006
Publisher
Scientific Publishing Division of MYU,
ISSN
0915-955X
NCID
AA10861036
Language
eng
NIIType
Journal Article
Text Version
出版社版
Old URI
Set
hirokoku-u