肥満細胞培養株RBL-2H3 細胞における,ヒスチジン およびカルノシンが脱顆粒に及ぼす影響
URI | http://harp.lib.hiroshima-u.ac.jp/hju/metadata/12269 | ||||||||||||||||||
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File |
論集66-03妻木.pdf
( 411.0 KB )
Open Date
:2019-02-25
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Title |
肥満細胞培養株RBL-2H3 細胞における,ヒスチジン およびカルノシンが脱顆粒に及ぼす影響
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Title Alternative |
Effect of Histidine and Carnosine on Degranulation in RBL-2H3
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Author |
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Subject |
allergy
histamine
histidine
HDC
RBL-2H3
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Abstract |
Most food allergies are caused by immunoglobulin epsilon (IgE)-dependent immediate immune responses. Upon ingestion of allergens that act as antigens, antigen-specific IgE antibodies are produced in the body, and sensitization is established through the binding of IgE antibodies to highaffinity IgE receptors on mast ells. When the same allergen invades again, owing to the acquired immune sensitivity, it binds to the specific IgE antibodies, thereby degranulating histamine and serotonin. Histamine is one of the several compounds responsible for causing allergic symptoms, and is synthesized via histidine decarboxylation by histidine decarboxylase (HDC). As it is one of the essential amino acids, the body obtains this compound through its diet. In this study, the influence of high levels of histidine on the synthesis and the degranulation of histamine were examined. |
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Journal Title |
広島女学院大学論集
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Volume |
66
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Spage |
33
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Epage |
42
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Published Date |
2019-02-28
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Publisher |
広島女学院大学
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ISSN |
0374-8057
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Language |
jpn
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NIIType |
Departmental Bulletin Paper
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Set |
hju
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