This paper examines and explores the essential, scope, and sustainability of Information and Intelligent Systems Engineering (IISE) toward the excellent engineering education and practice with capabilities accumulated throughout over three decades university history. The coming 21th century is an age of information and globalization in which unbounded competition and new civilization are spread out before us. This new century provides us with an opportunity of new challenge and great leap. Therefore, we are required to make the most of this opportunity to thrive the IISE department much more prosper. The IISE department has been making every possible effort to foster the creative and competent men and women who can positively cope with the wind of change. Finally, every aspect and possibilities of the multi-faceted curriculum of the IISE will be explored with comprehensive figures and a wide range of real-life problems.