Dynamic behavior of glass screen of low-rise steel frame building has been examined by earthquake response observations and simulation analysis. Strong-motion earthquake measurement was conducted at damaged a low-rise steel-frame building with glass screens to examine its vibration characteristics that could generate force on the glass screens. From the analysis and an earthquake observation done, it was confirmed that the glass screen at the corner of the building tends to be easily destroyed due to the influence of coupling with the torsional vibrations in addition to the large vibrations in out-of-plane direction.