<原著>正常ならびに糖尿病ラットにおける外因性GLP-1の代謝

URI http://harp.lib.hiroshima-u.ac.jp/pu-hiroshima/metadata/3433
File
Title
<原著>正常ならびに糖尿病ラットにおける外因性GLP-1の代謝
Title Alternative
<ORIGINAL ARTICLES>Kinetic analysis on exogenous GLP-1 in normal and diabetic rats
Author
氏名 大島 一洋
ヨミ オオシマ イチヨウ
別名 OSHIMA Ichiyo
氏名 坪倉 篤雄
ヨミ ツボクラ トクオ
別名 TSUBOKURA Tokuo
Subject
グルカゴン関連ペプチド1
貯蔵型
活性型
体内動態
正常および糖尿病ラット
GLP-1
full-sequence form
truncated form
pharmacokinetics
normal and storeptozotocin diabetic rat
Abstract

To elucidate the functions of pancreatic endocrine glands, we investigated the pharmacokinetics of full-sequence and truncated form of glucagon-like peptide 1 (GLP-1) in vivo, using radioimmunoassay for each peptide in normal and storeptozotocin (STZ) diabetic rats. The half-disappearance times (T1/2) and metabolic clearance rates (MCR) of truncated GLP-1,given as a bolus injection, were, respectively, as follows : T1/2 (min) 2.7±O.7 (mean±SD) and 5.9±1.5 ; MCR (ml・kg^-1・min^-1) 51.9±21.5 and 66.O±25.5. The T1/2 and MCR values were, respectively, shorter and larger than those of full-sequence GLP-1. The T1/2 and MCR values of constant infusion of truncated GLP-1 in STZ diabetic rats were, respectively, 3.1±1.1 min and 68.3±22.6 ml・kg^-1・min^-1,and these values were not different significantly from the respective values found in normal rat. These findings demonstrate that truncated GLP-1 degrades faster than the full-sequence form and may be an active form of GLP-1 in vivo.

Description

国立情報学研究所で電子化

Journal Title
広島県立保健福祉短期大学紀要
Volume
1
Issue
1
Spage
21
Epage
28
Published Date
1996-03
Publisher
広島県立保健福祉短期大学
ISSN
1342-0070
NCID
AA11318754
Language
jpn
NIIType
Departmental Bulletin Paper
Text Version
出版社版
Sort Key
07
Old URI
Set
pu-hiroshima