本研究では、キュウリエソを原料として麹菌で発酵させて作成した魚醤がラットの脂質代謝に及ぼす効果を検討した。Fisher-344系雄ラット7週齢、1群6匹ずつ4群を設けた。AIN-93G飼料組成を基本とした飼料を与えた群を対照(Cont)群とし、基本飼料+コレステロールを飼料とした群をChol-Cont群、基本飼料+コレステロール+粉末化した魚醤(FSPF)1%を飼料とした群をChol-F1群、基本飼料+コレステロール+FSPF3%を飼料とした群をChol-F3群とした。これらの飼料でラットを4週間飼育し、血清成分、肝臓中の脂質、トコフェロールについて検討した。その結果、体重増加量は、4群間で有意な差はみられなかった。血清脂質についてChol-Cont群とChol-F1群およびChol-F3群を比較検討したところ、血清総コレステロール(TC)値はChol-F1群、Chol-F3群で有意に高値を示し、魚醤の添加効果は認められなかった。血清トリグリセリド(TG)値はChol-F1群では、Chol-Cont群に比べ、有意の低い値であった。また、血清α-Toc値は、Chol-Cont群よりもChol-F1群、Chol-F3群で高い値を示した。さらに、肝臓中の脂質では、TG値はChol-Cont群、Chol-F1群、Chol-F3群の3群間で有意な差は認められなかった。今回の検討では、粉末化した魚醤の摂取により血清TG値の低下が認められたことから、キュウリエソを有効活用できる可能性のあることが示唆された。

"Our study examined the effects of fish sauce made from Maurolicus muelleri and fermentd with Aspergillus oryzae on lipid metabolism in rats. We sorted 24 male Fisher-344 rats, 7 weeks of age, into 4 groups after one week of extra breeding. The control group was fed a diet of AIN-93G composition ; the Chol-Cont group was fed the basic diet+cholesterol ; the Chol-F1 group was fed the basic diet+cholesterol+fish sauce in powder form (FSPF) that made up 1% of the total diet ; and the Chol-F3 group was fed the basic diet+cholesterol+FSPF that made up 3% of the total diet. The rats were fed on these diets 4 weeks, and the serum component, lipid, and tocopherol levels in their a livers were examined. The differences in body weight increases were not significant among the four groups. When the Chol-Cont, Chol-F1, and Chol-F3 groups were compared, the serum total cholesterol (TC) level in the Chol-Cont group showed serum lipid levels significantly higher than those of the Chol-F1 and Chol-F3 groups ; the effects of the fish sauce were not recognizable. When serum triglyceride (TG) levels were examined, the Chol-F1 group showed levels significantly lower than those of the Chol-Cont group. In addition, the Chol-F1 and Chol-F3 groups showed serum tocopherol levels significantly higher than those of the Chol-Cont group. Furthermore, no significant differences in TG levels were detected between the Chol-Cont, Chol-F1, and Chol-F3 groups. Because serum TG levels decreased significantly, it can be concluded that intake of Maurolicus muelleri was effective."

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国立情報学研究所で電子化