尿酸代謝における肝臓の生理的役割

URI http://harp.lib.hiroshima-u.ac.jp/pu-hiroshima/metadata/9961
File
Title
尿酸代謝における肝臓の生理的役割
Title Alternative
Physiological role in liver on uric acid metabolism in rats
Author
氏名 国信 清香
ヨミ クニノブ キヨカ
別名 Kuninobu Kiyoka
氏名 齋藤 亜衣子
ヨミ サトウ アイコ
別名 Saito Aiko
氏名 佐野 尚美
ヨミ サノ ナオミ
別名 Sano Naomi
氏名 西田 由香
ヨミ ニシダ ユカ
別名 Nishida Yuka
氏名 加藤 秀夫
ヨミ カトウ ヒデオ
別名 Kato Hideo
Abstract

The aim of the present study is to investigate the physiological role of the liver on uric acid metabolism in rats. We measured plasma uric acid levels in portal vein and hepatic vein in rats fed a standard diet or a high fat diet. The uric acid level of hepatic vain was lower than that of portal vain. This result showed that the liver was involved in uricolysis. In rats fed the high fat diet, the uric acid levels were elevated in both of portal and hepatic vains. The increase of visceral fats, which had caused by the high fat diets, would decrease a performance of uric acid metabolism in the liver. We also showed a significant positive correlation between serum uric acid level and abdominal circumference in human. In conclusion, our findings suggested that abstention from high fat diet and reduction of visceral fat are important for prevention of hyperuricemia.

Journal Title
県立広島大学人間文化学部紀要
Volume
6
Spage
55
Epage
60
Published Date
2011-02
Publisher
県立広島大学
ISSN
1346-7816
NCID
AA12116573
Language
jpn
NIIType
Departmental Bulletin Paper
Text Version
出版社版
Sort Key
08
Old URI
Set
pu-hiroshima