肝臓の糖質代謝リズムに関する研究 (1) : 特に摂食時刻に関して

URI http://harp.lib.hiroshima-u.ac.jp/pu-hiroshima/metadata/9959
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Title
肝臓の糖質代謝リズムに関する研究 (1) : 特に摂食時刻に関して
Title Alternative
Study on circadian rhythm of carbohydrate metabolism in the liver of rats : effect of feeding time
Author
氏名 出口 佳奈絵
ヨミ イデグチ カナエ
別名 Ideguchi Kanae
氏名 植田 さつき
ヨミ ウエダ サツキ
別名 Ueda Satsuki
氏名 齋藤 亜衣子
ヨミ サトウ アイコ
別名 Saito Aiko
氏名 佐野 尚美
ヨミ サノ ナオミ
別名 Sano Naomi
氏名 加藤 秀夫
ヨミ カトウ ヒデオ
別名 Kato Hideo
氏名 西田 由香
ヨミ ニシダ ユカ
別名 Nishida Yuka
Abstract

Circadian variations in the carbohydrate metabolism of liver, blood glucose responses to food intake were examined in rats kept on a 12-hr light-dark cycle and fed during a restricted time of day 10:00-16:00) for 4weeks. Blood glucose levels from a hepatic vein were maintained regardless of food intake to a specific time of day. The muscle glycogen rhythm appears when rats are allowed to eat, and maximal level in found immediately after the feeding time. On the other hand, the hepatic glucose increased slowly to high level. Difference between blood glucose level in a portal vein and a hepatic vein showed daily changes corresponding to the rhythm of food intake in rats. When the blood glucose level in a portal vein was higher than that in a hepatic vein, the utility of the glucose in the postprandial was increased. In the contrary case, the gluconeogenesis was increased in the fasting time. The circadian rhythm of the insulin degradation in the liver showed increased in the fasting time, and decreased by feeding time. From these results, carbohydrate metabolism in the liver showed circadian rhythm that was related to the food intake. We concluded that the regular eating habits were important for health maintenance because of a feeding time was also important for the metabolic control of carbohydrate in the liver.

Journal Title
県立広島大学人間文化学部紀要
Volume
6
Spage
25
Epage
33
Published Date
2011-02
Publisher
県立広島大学
ISSN
1346-7816
NCID
AA12116573
Language
jpn
NIIType
Departmental Bulletin Paper
Text Version
出版社版
Sort Key
05
Old URI
Set
pu-hiroshima